Megan Thee Stallion and Nicki Minaj went from "Hot Girl Summer" to hissing back and forth.

Megan Thee Stallion released her new single "Hiss" on Friday, which details the three-time Grammy Award winner's trials and triumphs throughout the past few years.

Though the rapper has topped the charts with buzzy collaborations alongside Cardi B, Beyoncé and more, she's faced public scrutiny and trauma after fellow rapper Tory Lanez shot the Houston native in July 2020. Lanez, whose real name is Daystar Peterson, was sentenced to 10 years in prison for the shooting in August.

In her previous single, "Cobra," about life post-shooting, Megan Thee Stallion opens up about her mental health struggles, rapping, "I'm sittin' in a dark room thinking, probably why I always end up drinking; (Yes), I'm very depressed."

In her first song of the year "Hiss," she raps that people "don't be mad at Megan," but that they're "mad at Megan's Law." The bars are an apparent reference to Minaj, who is married to registered sex offender Kenneth Penny.

Megan's Law is a federal law that requires registered sex offenders to provide their personal information to local law enforcement agencies. Petty was sentenced to probation and house arrest for failing to register as a sex offender in California.

More:Tory Lanez sentenced to 10 years in prison for shooting Megan Thee Stallion

"We appreciate and respect the Court’s decision granting the defense request for probation and home confinement," Petty's attorneys Michael Goldstein and Hagop Kuyumjian told USA TODAY in a statement at the time.

In response to the "Savage" rapper's shade, Minaj took to Instagram Live shortly after "Hiss" was released to preview a song of her own.

"She like 6 foot, I call her big foot," Minaj raps, before saying someone "fell off, I said get up on your good foot." The verse is an alleged reference to the 2020 shooting; Lanez was accused of shooting Megan in her feet.

"You have three Grammys and you have to learn how to rap on the beat and being comfortable in the music,” Minaj said before mocking Megan Thee Stallion's rap flow.

Minaj also liked several tweets from users that were aimed at her former collaborator. Megan Thee Stallion responded with an Instagram story where she was doubled over with her left hand covering her mouth, seemingly laughing at Minaj's response to "Hiss."

Social media users take issue with Megan Thee Stallion and Nicki Minaj

By Friday morning, a slew of social media users took sides in the feud.

"'Who wanna play wit Nicki' oh she don't play…she gets down omg Nicki," one user wrote on X, in reference to lyrics from Minaj's hit song "FTCU."

"Big Foot in the clubs would go crazy," one user wrote and Minaj later reposted. The rapper also quoted a post on X that said, "@NICKIMINAJ post a pic of ur feet," with a photo of her feet.

Many fans took to X to defend Megan Thee Stallion in response to the traded barbs.

"Nicki Minaj was a fresh new sound for so many millennial girls growing up. To have grown, become a woman myself & watch her legacy perish because she chose to marry a predator, enable rapists, and abusers, mock a woman who was shot? A shame. An embarrassment," one user commented on X.

"Just shows how much not having a Grammy burns her up inside," another said, while quoting the video of Minaj mocking Megan Thee Stallion's flow.

Contributing: Charles Trepany, Naledi Ushe